Publications

Martinez V.G., Pankova V., Kasny L.., Singh T., White I.J., Benjamin, A.C., Dertschnig S., Horsnell H.L., Kriston-Vizi J., Burden J., Huang P.H., Tape, C.J., Acton, S.E. Fibroblastic reticular cells control conduit matrix deposition during lymph node expansion. Cell Reports 2019 2810–2822

Acton, S.E. Bell A.J.D., Toseland D., Twelvetrees A.
Research Culture – A survey of new PIs in the UK
eLIFE 2019 8(e46827)

Makris S., Acton, S.E.,
The Stromal Niche guarding the gatekeepers
Immunity 2019 50(6) 1344-1356

Cabeza-Cabrerizo M., van Blijswijk J., Wienert S., Heim D., Jenkins R.P., Chakravarty P., Rogers N., Frederico B., Acton, S.E., Beerling E., van Rheenen J., Clevers H., Schraml B.U., Bajénoff M., Gerner M., Germain R.N, Sahai E., Klauschen F., Reis e Sousa C. Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors. Science Immunology 2019 4(33)

Martinez V.G., Park D., Acton, S.E. Immunotherapy – breaching the barriers for cancer treatment. Philosophical Transactions of the Royal Society B. 2019 374 (1779)

de Winde C.M., Matthews A.L, van Deventer S., van der Schaaf A., Tomlinson N.D., Yang J., Jansen E., Eble J.A., Nieswandt B., McGettrick H.M., Figdor C.G., Acton, S.E.., Tomlinson M.G., van Spriel A.B. C-type lectin-like receptor 2 (CLEC-2)-dependent DC migration is controlled by tetraspanin CD37. Journal of Cell Science. 2018 131(19).

Acton, S.E., & Reis E Sousa, C. Dendritic cells in remodeling of lymph nodes during immune responses. Immunological reviews, 271 (1), 221-229.

Zelenay S, van der Veen AG, Böttcher JP, Snelgrove KJ, Rogers N, Acton SE, Chakravarty P. Girotti, R.M. Marais, R., Quezada, S., Sahai, E., and Reis e Sousa, C. Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity. Cell. 2015 162(6):1257–70.

Fletcher A.L., Acton S.E., Knoblich, K. Lymph Node Fibroblastic Reticular Cells in Health and Disease. Nature Reviews Immunology 2015 15(6), 350-61

van Blijswijk J, Schraml B, Rogers N.C., Whitney P.G., Zelenay S., Acton S.E., Reis E Sousa C. Altered Lymph Node Composition in Diphtheria Toxin Receptor-Based Mouse Models To Ablate Dendritic Cells. J Immunol. 2014 Nov 19. pii: 1401999.

Acton S.E*., Farrugia A.J., Astarita J.L., Mourão-Sá D., Jenkins R.P., Nye E., Hooper S., van Blijswijk J., Rogers N.C., Snelgrove K.J., Rosewell I., Moita L.F., Stamp G., Turley S.J., Sahai E., Reis e Sousa C. CLEC-2+ Dendritic Cells Control Fibroblastic Reticular Network Tension and Lymph Node Expansion. Nature 2014 514, 498–502 (co-corresponding author)

Schraml B.U., van Blijswijk J., Zelenay S., Whitney P.G., Acton S.E., Filby A., Rogers N.C., Moncaut N., Carvajal J.J, Reis e Sousa C. A model for lineage tracing of dendritic cells in mice. Cell. 2013 154 (4), 843-858

Astarita J.L., Acton S.E., Turley S.J. Podoplanin: emerging functions in development, the immune system, and cancer. Front. Immun. 2012; 3: 283

Acton S.E., Astarita J.L., Malhotra D., Lukacs-Kornek V., Franz B., Hess P.R., Jakus Z., Kuligowski M., Fletcher A.L., Elpek K.G., Bellemare-Pelletier A., Sceats L., Reynoso E.D., Gonzalez S.F., Graham D.B., Chang J., Peters A., Woodruff M., Kim Y.A., Swat W., Morita T., Kuchroo V., Carroll M.C., Kahn M.L., Wucherpfennig K.W., Turley S.J. Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2. Immunity. 2012 37(2):276-89

Peters A., Pitcher L.A., Sullivan J.M., Mitsdoerffer M., Acton S.E., Franz B., Wucherpfennig K., Turley S., Carroll M.C., Sobel R.A., Bettelli E., Kuchroo V.K.. Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation. Immunity. 2011 35(6):986-96.

Lukacs-Kornek V., Malhotra D., Fletcher A.L., Acton S.E., Elpek K.G., Tayalia P., Collier A.R., Turley S.J. Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes. Nat Immunol. 2011 12(11):1096-104.

Fletcher A.L., Malhotra D., Acton S.E., Lukacs-Kornek V., Bellemare-Pelletier A., Curry M., Armant M. and Turley S.J. Reproducible isolation of lymph node stromal cells reveals site-dependent differences in fibroblastic reticular cells. Front. Immun. 2011 2:35

Levy C, Khaled M, Iliopoulos D, Janas MM, Schubert S, Pinner S, Chen PH, Li S, Fletcher AL, Yokoyama S, Scott KL, Garraway LA, Song JS, Granter SR, Turley SJ, Fisher DE, Novina CD. Intronic miR-211 assumes the tumor suppressive function of its host gene in melanoma. Mol. Cell 2010 40(5):841-9

Fletcher AL, Lukacs-Kornek V, Reynoso ED, Pinner SE, Bellemare-Pelletier A, Curry MS, Collier AR, Boyd RL, Turley SJ. Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions. Journal of Experimental Medicine.  2010 207(4):689-97

Giampieri S*, Pinner S, Sahai E. Intravital imaging illuminates transforming growth factor beta signaling switches during metastasis. Cancer Research 2010 70(9):3435-9 (*co-first author)

Pinner S., Jordan P, Sharrock K, Bazley L, Collinson L, Marais R, Bonvin E, Goding C, Sahai E. Intravital imaging reveals transient changes in pigment production and Brn2 expression during metastatic melanoma dissemination. Cancer Research 2009 69(20):7969-77

Pinner S.E. and Sahai E. Integrin-independent movement of immune cells. 2009 F1000 reports 1:67

Pinner S.E., Sahai E. PDK1 regulates cancer cell motility in three-dimensional environments by antagonising inhibition of ROCK1 by RhoE. Nature Cell Biology 2008 10(2):127-137

Sanz-Moreno V, Gadea G, Ahn J, Paterson H, Marra P, Pinner S, Sahai E, Marshall CJ. Rac activation and inactivation control plasticity of tumor cell movement. Cell 2008 135(3):510-23

Pinner S, Sahai E. Imaging amoeboid cell motility in vivo Journal of Microscopy 2008 231(3):441-5

Wyckoff JB, Pinner S.E., Gschmeissner S, Condeelis JS, Sahai E. ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo. Current Biology 2006 16(15):1515-23